Duluth police officers responded to a single-vehicle rollover shortly before 3:30 a.m. Tuesday on the 4200 block of London Road.
The two occupants of the vehicle were transported to the hospital with injuries, according to the Duluth Police Department. A 16-year-old female passenger had "significant" injuries, but was stable and conscious during the transport. The 21-year-old male driver had "minor" injuries.
The man was driving a 2016 Honda Odyssey east on London Road at a high rate of speed when he lost control of the vehicle around 42nd Avenue East.
The police department said impairment is believed to be a factor and that the investigation is ongoing.