The impetus of Moxie Hollow was to provide a space for local artists to create and sell their work.
The business, which opened Friday at 323 E. Superior St., will be half studio and half gallery for artists that make "functional art" such as T-shirts and purses, owner Erika Osterman said.
"People are crammed for space or don't want to deal with the mess, so I want to provide a space for them," said Osterman, also a painter, photographer and crafter, who will sell her "stuffed monsters" at the store.
The studio space will include two looms, two sewing machines, crafting tables and lockers. Local artists can rent the space for $20 a week or $50 a month, Osterman said.
Osterman, who has lived in Duluth eight years, said the store will provide tourists with unique Twin Ports goods.
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The store's open house, with live music, will be from 5-7 p.m. Saturday.